When a pharmacy transfers Schedule II drugs to a reverse distributor for destruction, what form must the reverse distributor issue to the pharmacy?

• A. DEA Form 222
• B. DEA Form 106
• C. DEA Form 41
• D. DEA Form 224

Answer: (A)

Tightly controlled Schedule II substances require a formal transfer document between registrants. When a pharmacy sends Schedule II drugs to a reverse distributor for destruction, the transfer is documented with DEA Form 222. This form records the exact drugs, strengths, quantities, and the involved registrants, creating an auditable trail for the DEA as possession changes hands. After destruction, a certificate of destruction (DEA Form 41) may be used to confirm completion, but the transfer itself is governed by the Form 222. Other forms have different purposes: Form 106 is for reporting theft or loss, and Form 224 is the registration form to handle controlled substances.