Which drug classes require warning about impairment of the ability to operate a vehicle or vessel and must be included as an auxiliary label?

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All of these drug classes can impair alertness and coordination, so they require a warning about impairment when driving or operating machinery. Muscle relaxants depress the central nervous system and commonly cause drowsiness, dizziness, and slowed reflexes, which can make driving unsafe. Antihistamines, especially the older ones, are well known for causing sedation and impaired driving ability, so a warning is needed. Some antipsychotic medications also have central nervous system depressant effects that slow reaction times and impair coordination, making driving hazardous. Because each class has a real potential to impair the ability to operate a vehicle or vessel, the auxiliary label warning must be included.